Peroxynitrite-induced Apoptosis in HL-60 Cells
نویسندگان
چکیده
منابع مشابه
Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells.
In this study, we show that caspases 2, 3, 6, and 7 were activated during peroxynitrite-induced apoptosis in human leukemia HL-60 cells and that processing of these caspases was accompanied by cleavage of poly(ADP-ribose) polymerase and lamin B. Treatment of cells with DEVD-fluoromethyl ketone (FMK), a selective inhibitor for caspase 3-like proteases, resulted in a marked diminution of apoptoti...
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The purpose of this study was to examine the effect of ethanol on apoptosis of human promyelocytic leukemia cell line HL-60 cells and search for a possible reason for reduced PMNs, monocytes, lymphocytes in the blood of alcoholics. Human promyelocytic leukemia cell line HL-60 cells was used as a model of apoptosis, with ethanol being the interfering factor. Qualitative and quantitative detectio...
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Objectives: Lantadene A (LA, 22β-angeloyloxy-3-oxoolean-12-en-28-oic acid) a pentacyclic, triterpenoid isolated from the leaves of the obnoxious weed, Lantana camara L. was evaluated for apoptosis induction in the human leukemia HL-60 cell line. Materials and Methods: The effect of LA on cell proliferation of HL-60 cancer cells was determined by using the MTT assay. The morphological effects of...
متن کاملPeroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease.
Apoptosis is an active process critical for the homeostasis of organisms. Enzymes of the caspase family are responsible for executing this process. We have previously shown that peroxynitrite (ONOO-), a biological product generated from the interaction of nitric oxide and superoxide, induces apoptosis of HL-60 cells. The aim of this study was to elucidate the mechanisms involved in the executio...
متن کاملImmunocytochemical Study on Microtubule Reorganization in HL-60 Leukemia Cells Undergoing Apoptosis
Background: Microtubules (MT) are important components of cell cytoskeleton and play key roles in cell motility mitosis and meiosis. They are also the targets of several anticancer agents which indicating their importance in maintaining cell viability. Microtubular reorganization contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.28.16487